Category: Pharmacology & Therapeutics
Keywords: PCP, clindamycin, primaquine, pentamidine, dapsone, atovaquone (PubMed Search)
Posted: 2/22/2011 by Bryan Hayes, PharmD
(Emailed: 3/5/2011)
(Updated: 3/5/2011)
Click here to contact Bryan Hayes, PharmD
Sulfamethoxazole (SMX)/trimethoprim (TMP) is the treatment of choice for PCP pneumonia. The IV formulation has been unavailable for almost a year due to shortage. It is contraindicated in patients with sulfa allergy. Here are the alternatives with adverse effects. You'll quickly see why pentamidine should generally be reserved for those with sulfa allergy and G6PD deficiency.
Mild-to-moderate disease:
Moderate-to-severe disease:
Adverse Effects:
Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. MMWR April 10, 2009 / 58(RR04);1-198.
Category: Pharmacology & Therapeutics
Keywords: iohexol, iodixanol, radio contrast media, immediate hypersensitivity reactions (PubMed Search)
Posted: 2/5/2011 by Bryan Hayes, PharmD
Click here to contact Bryan Hayes, PharmD
Many patients report an allergy to iodinated RCM, sometimes adding to the complexity of diagnostic decision making. Here are a few pearls to help:
Bottom line: Despite the lack of cross reactivity with shellfish/iodine allergies AND the very low risk associated with today’s low osmolality agents, premedication is still indicated in patient’s with a history of IHR to RCM.